Synthesis of a Novel Polymeric Material Folate-Poly(2-ethyl-2-oxazoline)-Distearoyl Phosphatidyl Ethanolamine Tri-Block Polymer for Dual Receptor and pH-Sensitive Targeting Liposome
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pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system
BACKGROUND In this study, a pH and temperature dual-sensitive liposome gel based on a novel cleavable hydrazone-based pH-sensitive methoxy polyethylene glycol 2000-hydrazone-cholesteryl hemisuccinate (mPEG-Hz-CHEMS) polymer was used for vaginal administration. METHODS The pH-sensitive, cleavable mPEG-Hz-CHEMS was designed as a modified pH-sensitive liposome that would selectively degrade unde...
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A synthesis of racemic diether analogues of glyceryl phosphatides is reported which is applicable to unsaturated aliphatic substituents. The "oleyl" diether analogue of phosphatidyl ethanolamine has been synthesized.
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The long term in vivo biocompatibility is an essential feature for the design and development of sustained drug release carriers. In the recent intraocular drug delivery studies, hydrogels were suggested as sustained release carriers. The biocompatibility test for these hydrogels, however, was commonly performed only through in vitro cell culture examination, which is insufficient before the cl...
متن کاملHighly selective polymer electrolyte membranes consisting of poly(2-ethyl-2-oxazoline) and Cu(NO3)2 for SF6 separation
Polymer electrolyte membranes consisting of Cu(NO3)2 and poly(2-ethyl-2-oxazoline) (POZ) were prepared for SF6/N2 separation. It was anticipated that repulsive forces would be operative between the negative charge of water and the F atoms of SF6 when Cu(NO3)2 in the composite was solvated by water, and that the barrier effect of Cu(2+) ions would be activated. In fact, Cu(NO3)2 solvated by wate...
متن کاملFolic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation
BACKGROUND A novel dual ligand-modified liposome, folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier (FP-Lipo), was designed to overcome the nonselectivity of conventional penetrating peptide-tagged nanoparticulates and to provide the advantage of selective targeting of the folic acid receptor, which is frequently overexpressed on epithelial cancer cells. METHODS FP-Lipo was p...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2013
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.c12-00951